Human MOSC2 (MARC2) activation kit by CRISPRa

CAT#: GA110437

MARC2 CRISPRa kit - CRISPR gene activation of human mitochondrial amidoxime reducing component 2

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: MARC2
• Locus ID: 54996
• Kit Components:

  GA110437G1, MARC2 gRNA vector 1 in pCas-Guide-CRISPRa

  GA110437G2, MARC2 gRNA vector 2 in pCas-Guide-CRISPRa

  GA110437G3, MARC2 gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001317338, NM_001331042, NM_017898
• Synonyms: MOSC2
• Summary: The protein encoded by this gene is an enzyme found in the outer mitochondrial membrane that reduces N-hydroxylated substrates. The encoded protein uses molybdenum as a cofactor and cytochrome b5 type B and NADH cytochrome b5 reductase as accessory proteins. One type of substrate used is N-hydroxylated nucleotide base analogues, which can be toxic to a cell. Other substrates include N(omega)-hydroxy-L-arginine (NOHA) and amidoxime prodrugs, which are activated by the encoded enzyme. Multiple transcript variants encoding the different isoforms have been found for this gene. [provided by RefSeq, Sep 2016]