Human RNMTL1 (MRM3) activation kit by CRISPRa

CAT#: GA110579

MRM3 CRISPRa kit - CRISPR gene activation of human mitochondrial rRNA methyltransferase 3

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: MRM3
• Locus ID: 55178
• Kit Components:

  GA110579G1, MRM3 gRNA vector 1 in pCas-Guide-CRISPRa

  GA110579G2, MRM3 gRNA vector 2 in pCas-Guide-CRISPRa

  GA110579G3, MRM3 gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001317947, NM_018146
• Synonyms: RMTL1; RNMTL1
• Summary: Efficient translation of mitochondrial-derived transcripts requires proper assembly of the large subunit of the mitochondrial ribosome. Central to the biogenesis of this large subunit is the A-loop of mitochondrial 16S rRNA, which is modified by three rRNA methyltransferases located near mtDNA nucleoids. The protein encoded by this gene methylates G(1370) of 16S rRNA, and this modification is necessary for proper ribosomal large subnit assembly. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2015]