Human TMEM100 activation kit by CRISPRa

CAT#: GA110661

TMEM100 CRISPRa kit - CRISPR gene activation of human transmembrane protein 100

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: TMEM100
• Locus ID: 55273
• Kit Components:

  GA110661G1, TMEM100 gRNA vector 1 in pCas-Guide-CRISPRa

  GA110661G2, TMEM100 gRNA vector 2 in pCas-Guide-CRISPRa

  GA110661G3, TMEM100 gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001099640, NM_018286
• Synonyms: FLJ10970; FLJ37856
• Summary: Plays a role during embryonic arterial endothelium differentiation and vascular morphogenesis through the ACVRL1 receptor-dependent signaling pathway upon stimulation by bone morphogenetic proteins, such as GDF2/BMP9 and BMP10. Involved in the regulation of nociception, acting as a modulator of the interaction between TRPA1 and TRPV1, two molecular sensors and mediators of pain signals in dorsal root ganglia (DRG) neurons. Mechanistically, it weakens their interaction, thereby releasing the inhibition of TRPA1 by TRPV1 and increasing the single-channel open probability of the TRPA1-TRPV1 complex. [UniProtKB/Swiss-Prot Function]