Human HDAC8 activation kit by CRISPRa

CAT#: GA111031

HDAC8 CRISPRa kit - CRISPR gene activation of human histone deacetylase 8

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: HDAC8
• Locus ID: 55869
• Kit Components:

  GA111031G1, HDAC8 gRNA vector 1 in pCas-Guide-CRISPRa

  GA111031G2, HDAC8 gRNA vector 2 in pCas-Guide-CRISPRa

  GA111031G3, HDAC8 gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001166418, NM_001166419, NM_001166420, NM_001166422, NM_001166448, NM_018486, NR_051952
• Synonyms: CDA07; CDLS5; HD8; HDACL1; MRXS6; RPD3; WTS
• Summary: Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene belongs to class I of the histone deacetylase family. It catalyzes the deacetylation of lysine residues in the histone N-terminal tails and represses transcription in large multiprotein complexes with transcriptional co-repressors. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2009]