Human ASAH2 activation kit by CRISPRa

CAT#: GA111201

ASAH2 CRISPRa kit - CRISPR gene activation of human N-acylsphingosine amidohydrolase 2

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: ASAH2
• Locus ID: 56624
• Kit Components:

  GA111201G1, ASAH2 gRNA vector 1 in pCas-Guide-CRISPRa

  GA111201G2, ASAH2 gRNA vector 2 in pCas-Guide-CRISPRa

  GA111201G3, ASAH2 gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001143974, NM_019893
• Synonyms: BCDase; HNAC1; LCDase; N-CDase; NCDase
• Summary: Ceramidases (EC 3.5.1.23), such as ASAH2, catalyze hydrolysis of the N-acyl linkage of ceramide, a second messenger in a variety of cellular events, to produce sphingosine. Sphingosine exerts both mitogenic and apoptosis-inducing activities, and its phosphorylated form functions as an intra- and intercellular second messenger (see MIM 603730) (Mitsutake et al., 2001 [PubMed 11328816]). [supplied by OMIM, Mar 2008]