Human MEPE activation kit by CRISPRa

CAT#: GA111301

MEPE CRISPRa kit - CRISPR gene activation of human matrix extracellular phosphoglycoprotein

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: MEPE
• Locus ID: 56955
• Kit Components:

  GA111301G1, MEPE gRNA vector 1 in pCas-Guide-CRISPRa

  GA111301G2, MEPE gRNA vector 2 in pCas-Guide-CRISPRa

  GA111301G3, MEPE gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001184694, NM_001184695, NM_001184696, NM_001184697, NM_001291183, NM_020203
• Synonyms: OF45
• Summary: This gene encodes a secreted calcium-binding phosphoprotein that belongs to the small integrin-binding ligand, N-linked glycoprotein (SIBLING) family of proteins. Members of this family are components of the extracellular matrix of bone and dentin and regulate bone mineralization. Deficiency of a similar protein in mouse results in increased bone mass. Mice lacking this gene are resistant to aging-related trabecular bone loss. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2014]