Human CHD8 activation kit by CRISPRa

CAT#: GA111679

CHD8 CRISPRa kit - CRISPR gene activation of human chromodomain helicase DNA binding protein 8

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: CHD8
• Locus ID: 57680
• Kit Components:

  GA111679G1, CHD8 gRNA vector 1 in pCas-Guide-CRISPRa

  GA111679G2, CHD8 gRNA vector 2 in pCas-Guide-CRISPRa

  GA111679G3, CHD8 gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001170629, NM_020920
• Synonyms: AUTS18; HELSNF1
• Summary: This gene encodes a member of the chromodomain-helicase-DNA binding protein family, which is characterized by a SNF2-like domain and two chromatin organization modifier domains. The encoded protein also contains brahma and kismet domains, which are common to the subfamily of chromodomain-helicase-DNA binding proteins to which this protein belongs. This gene has been shown to function in several processes that include transcriptional regulation, epigenetic remodeling, promotion of cell proliferation, and regulation of RNA synthesis. Allelic variants of this gene are associated with autism spectrum disorder. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2016]