Human PRDM16 activation kit by CRISPRa

CAT#: GA111942

PRDM16 CRISPRa kit - CRISPR gene activation of human PR/SET domain 16

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: PRDM16
• Locus ID: 63976
• Kit Components:

  GA111942G1, PRDM16 gRNA vector 1 in pCas-Guide-CRISPRa

  GA111942G2, PRDM16 gRNA vector 2 in pCas-Guide-CRISPRa

  GA111942G3, PRDM16 gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_022114, NM_199454
• Synonyms: CMD1LL; LVNC8; MEL1; PFM13
• Summary: The reciprocal translocation t(1;3)(p36;q21) occurs in a subset of myelodysplastic syndrome (MDS) and acute myeloid leukemia (AML). This gene is located near the 1p36.3 breakpoint and has been shown to be specifically expressed in the t(1:3)(p36,q21)-positive MDS/AML. The protein encoded by this gene is a zinc finger transcription factor and contains an N-terminal PR domain. The translocation results in the overexpression of a truncated version of this protein that lacks the PR domain, which may play an important role in the pathogenesis of MDS and AML. Alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]