Human ALDH8A1 activation kit by CRISPRa

CAT#: GA112089

ALDH8A1 CRISPRa kit - CRISPR gene activation of human aldehyde dehydrogenase 8 family member A1

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: ALDH8A1
• Locus ID: 64577
• Kit Components:

  GA112089G1, ALDH8A1 gRNA vector 1 in pCas-Guide-CRISPRa

  GA112089G2, ALDH8A1 gRNA vector 2 in pCas-Guide-CRISPRa

  GA112089G3, ALDH8A1 gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001193480, NM_022568, NM_170771
• Synonyms: ALDH12; DJ352A20.2
• Summary: This gene encodes a member of the aldehyde dehydrogenase family of proteins. The encoded protein has been implicated in the synthesis of 9-cis-retinoic acid and in the breakdown of the amino acid tryptophan. This enzyme converts 9-cis-retinal into the retinoid X receptor ligand 9-cis-retinoic acid, and has approximately 40-fold higher activity with 9-cis-retinal than with all-trans-retinal. In addition, this enzyme has been shown to catalyze the conversion of 2-aminomuconic semialdehyde to 2-aminomuconate in the kynurenine pathway of tryptophan catabolism. [provided by RefSeq, Jul 2018]