Human NMNAT1 activation kit by CRISPRa

CAT#: GA112159

NMNAT1 CRISPRa kit - CRISPR gene activation of human nicotinamide nucleotide adenylyltransferase 1

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: NMNAT1
• Locus ID: 64802
• Kit Components:

  GA112159G1, NMNAT1 gRNA vector 1 in pCas-Guide-CRISPRa

  GA112159G2, NMNAT1 gRNA vector 2 in pCas-Guide-CRISPRa

  GA112159G3, NMNAT1 gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001297778, NM_001297779, NM_022787
• Synonyms: LCA9; NMNAT; PNAT1
• Summary: This gene encodes an enzyme which catalyzes a key step in the biosynthesis of nicotinamide adenine dinucleotide (NAD). The encoded enzyme is one of several nicotinamide nucleotide adenylyltransferases, and is specifically localized to the cell nucleus. Activity of this protein leads to the activation of a nuclear deacetylase that functions in the protection of damaged neurons. Mutations in this gene have been associated with Leber congenital amaurosis 9. Alternative splicing results in multiple transcript variants. Pseudogenes of this gene are located on chromosomes 1, 3, 4, 14, and 15. [provided by RefSeq, Jul 2014]