Human ZNF426 activation kit by CRISPRa

CAT#: GA112360

ZNF426 CRISPRa kit - CRISPR gene activation of human zinc finger protein 426

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: ZNF426
• Locus ID: 79088
• Kit Components:

  GA112360G1, ZNF426 gRNA vector 1 in pCas-Guide-CRISPRa

  GA112360G2, ZNF426 gRNA vector 2 in pCas-Guide-CRISPRa

  GA112360G3, ZNF426 gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001300883, NM_001318055, NM_001318056, NM_024106
• Synonyms: K-RBP
• Summary: Kaposi's sarcoma-associated herpesvirus (KSHV) can be reactivated from latency by the viral protein RTA. The protein encoded by this gene is a zinc finger transcriptional repressor that interacts with RTA to modulate RTA-mediated reactivation of KSHV. While the encoded protein can repress KSHV reactivation, RTA can induce degradation of this protein through the ubiquitin-proteasome pathway to overcome the repression. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2015]