Human CHAC1 activation kit by CRISPRa

CAT#: GA112365

CHAC1 CRISPRa kit - CRISPR gene activation of human ChaC glutathione specific gamma-glutamylcyclotransferase 1

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: CHAC1
• Locus ID: 79094
• Kit Components:

  GA112365G1, CHAC1 gRNA vector 1 in pCas-Guide-CRISPRa

  GA112365G2, CHAC1 gRNA vector 2 in pCas-Guide-CRISPRa

  GA112365G3, CHAC1 gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001142776, NM_024111
• Synonyms: MGC4504
• Summary: This gene encodes a member of the gamma-glutamylcyclotransferase family of proteins. The encoded protein has been shown to promote neuronal differentiation by deglycination of the Notch receptor, which prevents receptor maturation and inhibits Notch signaling. This protein may also play a role in the unfolded protein response, and in regulation of glutathione levels and oxidative balance in the cell. Elevated expression of this gene may indicate increased risk of cancer recurrence among breast and ovarian cancer patients. [provided by RefSeq, Sep 2016]