Human RNASEH2B activation kit by CRISPRa

CAT#: GA112493

RNASEH2B CRISPRa kit - CRISPR gene activation of human ribonuclease H2 subunit B

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: RNASEH2B
• Locus ID: 79621
• Kit Components:

  GA112493G1, RNASEH2B gRNA vector 1 in pCas-Guide-CRISPRa

  GA112493G2, RNASEH2B gRNA vector 2 in pCas-Guide-CRISPRa

  GA112493G3, RNASEH2B gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001142279, NM_024570
• Synonyms: AGS2; DLEU8
• Summary: RNase H2 is composed of a single catalytic subunit (A) and two non-catalytic subunits (B and C) and specifically degrades the RNA of RNA:DNA hybrids. The protein encoded by this gene is the non-catalytic B subunit of RNase H2, which is thought to play a role in DNA replication. Multiple transcript variants encoding different isoforms have been found for this gene. Defects in this gene are a cause of Aicardi-Goutieres syndrome type 2 (AGS2). [provided by RefSeq, Nov 2008]