Human SRD5A3 activation kit by CRISPRa

CAT#: GA112513

SRD5A3 CRISPRa kit - CRISPR gene activation of human steroid 5 alpha-reductase 3

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: SRD5A3
• Locus ID: 79644
• Kit Components:

  GA112513G1, SRD5A3 gRNA vector 1 in pCas-Guide-CRISPRa

  GA112513G2, SRD5A3 gRNA vector 2 in pCas-Guide-CRISPRa

  GA112513G3, SRD5A3 gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_024592
• Synonyms: CDG1P; CDG1Q; KRIZI; SRD5A2L; SRD5A2L1
• Summary: The protein encoded by this gene belongs to the steroid 5-alpha reductase family, and polyprenol reductase subfamily. It is involved in the production of androgen 5-alpha-dihydrotestosterone (DHT) from testosterone, and maintenance of the androgen-androgen receptor activation pathway. This protein is also necessary for the conversion of polyprenol into dolichol, which is required for the synthesis of dolichol-linked monosaccharides and the oligosaccharide precursor used for N-linked glycosylation of proteins. Mutations in this gene are associated with congenital disorder of glycosylation type Iq. [provided by RefSeq, Mar 2011]