Human B7H4 (VTCN1) activation kit by CRISPRa

CAT#: GA112543

VTCN1 CRISPRa kit - CRISPR gene activation of human V-set domain containing T cell activation inhibitor 1

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: VTCN1
• Locus ID: 79679
• Kit Components:

  GA112543G1, VTCN1 gRNA vector 1 in pCas-Guide-CRISPRa

  GA112543G2, VTCN1 gRNA vector 2 in pCas-Guide-CRISPRa

  GA112543G3, VTCN1 gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001253849, NM_001253850, NM_024626, NR_045603, NR_045604
• Synonyms: B7-H4; B7h.5; B7H4; B7S1; B7X; PRO1291; VCTN1
• Summary: This gene encodes a protein belonging to the B7 costimulatory protein family. Proteins in this family are present on the surface of antigen-presenting cells and interact with ligand bound to receptors on the surface of T cells. Studies have shown that high levels of the encoded protein has been correlated with tumor progression. A pseudogene of this gene is located on chromosome 20. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2011]