Human L2HGDH activation kit by CRISPRa

CAT#: GA112746

L2HGDH CRISPRa kit - CRISPR gene activation of human L-2-hydroxyglutarate dehydrogenase

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: L2HGDH
• Locus ID: 79944
• Kit Components:

  GA112746G1, L2HGDH gRNA vector 1 in pCas-Guide-CRISPRa

  GA112746G2, L2HGDH gRNA vector 2 in pCas-Guide-CRISPRa

  GA112746G3, L2HGDH gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_024884
• Synonyms: C14orf160; L2HGA
• Summary: This gene encodes L-2-hydroxyglutarate dehydrogenase, a FAD-dependent enzyme that oxidizes L-2-hydroxyglutarate to alpha-ketoglutarate in a variety of mammalian tissues. Mutations in this gene cause L-2-hydroxyglutaric aciduria, a rare autosomal recessive neurometabolic disorder resulting in moderate to severe cognitive disability. [provided by RefSeq, Jul 2008]