Human EDEM3 activation kit by CRISPRa

CAT#: GA112897

EDEM3 CRISPRa kit - CRISPR gene activation of human ER degradation enhancing alpha-mannosidase like protein 3

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: EDEM3
• Locus ID: 80267
• Kit Components:

  GA112897G1, EDEM3 gRNA vector 1 in pCas-Guide-CRISPRa

  GA112897G2, EDEM3 gRNA vector 2 in pCas-Guide-CRISPRa

  GA112897G3, EDEM3 gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001319960, NM_025191, NR_135118
• Synonyms: C1orf22
• Summary: Quality control in the endoplasmic reticulum (ER) ensures that only properly folded proteins are retained in the cell through recognition and degradation of misfolded or unassembled proteins. EDEM3 belongs to a group of proteins that accelerate degradation of misfolded glycoproteins in the ER (Hirao et al., 2006 [PubMed 16431915]). [supplied by OMIM, Mar 2008]