Human TEM8 (ANTXR1) activation kit by CRISPRa

CAT#: GA113404

ANTXR1 CRISPRa kit - CRISPR gene activation of human ANTXR cell adhesion molecule 1

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: ANTXR1
• Locus ID: 84168
• Kit Components:

  GA113404G1, ANTXR1 gRNA vector 1 in pCas-Guide-CRISPRa

  GA113404G2, ANTXR1 gRNA vector 2 in pCas-Guide-CRISPRa

  GA113404G3, ANTXR1 gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_018153, NM_032208, NM_053034
• Synonyms: ATR; GAPO; TEM8
• Summary: This gene encodes a type I transmembrane protein and is a tumor-specific endothelial marker that has been implicated in colorectal cancer. The encoded protein has been shown to also be a docking protein or receptor for Bacillus anthracis toxin, the causative agent of the disease, anthrax. The binding of the protective antigen (PA) component, of the tripartite anthrax toxin, to this receptor protein mediates delivery of toxin components to the cytosol of cells. Once inside the cell, the other two components of anthrax toxin, edema factor (EF) and lethal factor (LF) disrupt normal cellular processes. Three alternatively spliced variants that encode different protein isoforms have been described. [provided by RefSeq, Oct 2008]