Human MRI1 activation kit by CRISPRa

CAT#: GA113444

MRI1 CRISPRa kit - CRISPR gene activation of human methylthioribose-1-phosphate isomerase 1

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: MRI1
• Locus ID: 84245
• Kit Components:

  GA113444G1, MRI1 gRNA vector 1 in pCas-Guide-CRISPRa

  GA113444G2, MRI1 gRNA vector 2 in pCas-Guide-CRISPRa

  GA113444G3, MRI1 gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001031727, NM_032285, NM_001329572, NR_138051
• Synonyms: MRDI; MTNA; Ypr118w
• Summary: This enzyme functions in the methionine salvage pathway by catalyzing the interconversion of methylthioribose-1-phosphate and methythioribulose-1-phosphate. Elevated expression of the encoded protein is associated with metastatic melanoma and this protein promotes melanoma cell invasion independent of its enzymatic activity. Mutations in this gene may be associated with vanishing white matter disease (VMWD). [provided by RefSeq, Jul 2016]