Human LNX1 activation kit by CRISPRa

CAT#: GA113670

LNX1 CRISPRa kit - CRISPR gene activation of human ligand of numb-protein X 1

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: LNX1
• Locus ID: 84708
• Kit Components:

  GA113670G1, LNX1 gRNA vector 1 in pCas-Guide-CRISPRa

  GA113670G2, LNX1 gRNA vector 2 in pCas-Guide-CRISPRa

  GA113670G3, LNX1 gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001126328, NM_032622
• Synonyms: LNX; MPDZ; PDZRN2
• Summary: This gene encodes a membrane-bound protein that is involved in signal transduction and protein interactions. The encoded product is an E3 ubiquitin-protein ligase, which mediates ubiquitination and subsequent proteasomal degradation of proteins containing phosphotyrosine binding (PTB) domains. This protein may play an important role in tumorogenesis. Alternatively spliced transcript variants encoding distinct isoforms have been described. A pseudogene, which is located on chromosome 17, has been identified for this gene. [provided by RefSeq, Jul 2008]