Human ACMSD activation kit by CRISPRa

CAT#: GA115099

ACMSD CRISPRa kit - CRISPR gene activation of human aminocarboxymuconate semialdehyde decarboxylase

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: ACMSD
• Locus ID: 130013
• Kit Components:

  GA115099G1, ACMSD gRNA vector 1 in pCas-Guide-CRISPRa

  GA115099G2, ACMSD gRNA vector 2 in pCas-Guide-CRISPRa

  GA115099G3, ACMSD gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001307983, NM_138326
• Summary: The neuronal excitotoxin quinolinate is an intermediate in the de novo synthesis pathway of NAD from tryptophan, and has been implicated in the pathogenesis of several neurodegenerative disorders. Quinolinate is derived from alpha-amino-beta-carboxy-muconate-epsilon-semialdehyde (ACMS). ACMSD (ACMS decarboxylase; EC 4.1.1.45) can divert ACMS to a benign catabolite and thus prevent the accumulation of quinolinate from ACMS. [supplied by OMIM, Oct 2004]