Human SPATA18 activation kit by CRISPRa

CAT#: GA115180

SPATA18 CRISPRa kit - CRISPR gene activation of human spermatogenesis associated 18

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: SPATA18
• Locus ID: 132671
• Kit Components:

  GA115180G1, SPATA18 gRNA vector 1 in pCas-Guide-CRISPRa

  GA115180G2, SPATA18 gRNA vector 2 in pCas-Guide-CRISPRa

  GA115180G3, SPATA18 gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001297608, NM_001346102, NM_001346103, NM_145263, NR_123728, NR_144359
• Synonyms: Mieap; SPETEX1
• Summary: This gene encodes a p53-inducible protein that is able to induce lysosome-like organelles within mitochondria that eliminate oxidized mitochondrial proteins, thereby contributing to mitochondrial quality control. Dysregulation of mitochondrial quality control is associated with cancer and degenerative diseases. The encoded protein mediates accumulation of the lysosome-like mitochondrial organelles through interaction with B cell lymphoma 2 interacting protein 3 and B cell lymphoma 2 interacting protein 3 like at the outer mitochondrial membrane, which allows translocation of lysosomal proteins to the mitochondrial matrix from the cytosol. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2016]