Human VTI1A activation kit by CRISPRa

CAT#: GA115450

VTI1A CRISPRa kit - CRISPR gene activation of human vesicle transport through interaction with t-SNAREs 1A

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: VTI1A
• Locus ID: 143187
• Kit Components:

  GA115450G1, VTI1A gRNA vector 1 in pCas-Guide-CRISPRa

  GA115450G2, VTI1A gRNA vector 2 in pCas-Guide-CRISPRa

  GA115450G3, VTI1A gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001318203, NM_001318205, NM_145206, NR_134521, NR_134522, NR_134523, NM_001365710, NM_001365712, NM_001365713, NM_001365714, NM_001365711
• Synonyms: MMDS3; MVti1; Vti1-rp2; VTI1RP2
• Summary: The protein encoded by this gene is a member of the family of soluble N-ethylmaleimide-sensitive fusion protein-attachment protein receptors (SNAREs) that function in intracellular trafficking. This family member is involved in vesicular transport between endosomes and the trans-Golgi network. It is a vesicle-associated SNARE (v-SNARE) that interacts with target membrane SNAREs (t-SNAREs). Polymorphisms in this gene have been associated with binocular function, and also with susceptibility to colorectal and lung cancers. A recurrent rearrangement has been found between this gene and the transcription factor 7-like 2 (TCF7L2) gene in colorectal cancers. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2015]