Human Repulsive Guidance Molecule C (HFE2) activation kit by CRISPRa
CAT#: GA115681
HJV CRISPRa kit - CRISPR gene activation of human hemojuvelin BMP co-receptor
Find the corresponding CRISPRi Inhibitor Kit
USD 1,290.00
2 Weeks*
Specifications
Product Data | |
Format | 3gRNAs, 1 scramble ctrl and 1 enhancer vector |
Symbol | HJV |
Locus ID | 148738 |
Kit Components | GA115681G1, HJV gRNA vector 1 in pCas-Guide-CRISPRa GA115681G2, HJV gRNA vector 2 in pCas-Guide-CRISPRa GA115681G3, HJV gRNA vector 3 in pCas-Guide-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100058 |
Disclaimer | The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc. |
Reference Data | |
RefSeq | NM_001316767, NM_145277, NM_202004, NM_213652, NM_213653 |
Synonyms | HFE2A; HJV; JH; RGMC |
Summary | The product of this gene is involved in iron metabolism. It may be a component of the signaling pathway which activates hepcidin or it may act as a modulator of hepcidin expression. It could also represent the cellular receptor for hepcidin. Two uORFs in the 5' UTR negatively regulate the expression and activity of the encoded protein. Alternatively spliced transcript variants encoding different isoforms have been identified for this gene. Defects in this gene are the cause of hemochromatosis type 2A, also called juvenile hemochromatosis (JH). JH is an early-onset autosomal recessive disorder due to severe iron overload resulting in hypogonadotrophic hypogonadism, hepatic fibrosis or cirrhosis and cardiomyopathy, occurring typically before age of 30. [provided by RefSeq, Oct 2015] |
Documents
Product Manuals |
FAQs |
SDS |
Resources
Other Versions
SKU | Description | Size | Price |
---|---|---|---|
KN410553 | HFE2 - KN2.0, Human gene knockout kit via CRISPR, non-homology mediated. |
USD 1,290.00 |
{0} Product Review(s)
Be the first one to submit a review