Human UBR1 activation kit by CRISPRa

CAT#: GA116293

UBR1 CRISPRa kit - CRISPR gene activation of human ubiquitin protein ligase E3 component n-recognin 1

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: UBR1
• Locus ID: 197131
• Kit Components:

  GA116293G1, UBR1 gRNA vector 1 in pCas-Guide-CRISPRa

  GA116293G2, UBR1 gRNA vector 2 in pCas-Guide-CRISPRa

  GA116293G3, UBR1 gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_174916
• Synonyms: JBS
• Summary: The N-end rule pathway is one proteolytic pathway of the ubiquitin system. The recognition component of this pathway, encoded by this gene, binds to a destabilizing N-terminal residue of a substrate protein and participates in the formation of a substrate-linked multiubiquitin chain. This leads to the eventual degradation of the substrate protein. The protein described in this record has a RING-type zinc finger and a UBR-type zinc finger. Mutations in this gene have been associated with Johanson-Blizzard syndrome. [provided by RefSeq, Jul 2008]