Mouse Angpt4 activation kit by CRISPRa

CAT#: GA200121

Angpt4 CRISPRa kit - CRISPR gene activation of mouse angiopoietin 4

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: Angpt4
• Locus ID: 11602
• Kit Components:

  GA200121G1, Angpt4 gRNA vector 1 in pCas-Guide-CRISPRa

  GA200121G2, Angpt4 gRNA vector 2 in pCas-Guide-CRISPRa

  GA200121G3, Angpt4 gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_009641
• Synonyms: Agpt4; ANG-3; ANG-4; Ang3
• Summary: This gene is a member of the angiopoietin family of secreted growth factors comprising Angiopoietins-1, -2, and -3, all of which bind the TEK Receptor Tyrosine Kinase. Angiopoietin/TEK Receptor Tyrosine Kinase signaling is involved in survival and migration of endothelial cells and regulates vascular remodeling and maintenance of vascular integrity. Angiopoietin/TEK Receptor Tyrosine Kinase signaling is also required for lymphangiogenesis. Family members bind TEK Receptor Tyrosine Kinase as multimeric clusters but their oligomerization properties differ from one another and this is thought to provide a mechanistic basis for their distinct physiologic roles. [provided by RefSeq, Jul 2016]