Mouse Ank1 activation kit by CRISPRa

CAT#: GA200186

Ank1 CRISPRa kit - CRISPR gene activation of mouse ankyrin 1, erythroid

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: Ank1
• Locus ID: 11733
• Kit Components:

  GA200186G1, Ank1 gRNA vector 1 in pCas-Guide-CRISPRa

  GA200186G2, Ank1 gRNA vector 2 in pCas-Guide-CRISPRa

  GA200186G3, Ank1 gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001110783, NM_001277280, NM_001277281, NM_001277284, NM_001277286, NM_001277289, NM_001310436, NM_001310437, NM_031158, NR_102385, NR_102386
• Synonyms: Ank-1; nb; pale
• Summary: Attaches integral membrane proteins to cytoskeletal elements; binds to the erythrocyte membrane protein band 4.2, to Na-K ATPase, to the lymphocyte membrane protein GP85, and to the cytoskeletal proteins fodrin, tubulin, vimentin and desmin. Erythrocyte ankyrins also link spectrin (beta chain) to the cytoplasmic domain of the erythrocytes anion exchange protein; they retain most or all of these binding functions. In skeletal muscle, isoform Mu7 together with obscurin may provide a molecular link between the sarcoplasmic reticulum and myofibrils. [UniProtKB/Swiss-Prot Function]