Mouse Ctsc activation kit by CRISPRa

CAT#: GA200947

Ctsc CRISPRa kit - CRISPR gene activation of mouse cathepsin C

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: Ctsc
• Locus ID: 13032
• Kit Components:

  GA200947G1, Ctsc gRNA vector 1 in pCas-Guide-CRISPRa

  GA200947G2, Ctsc gRNA vector 2 in pCas-Guide-CRISPRa

  GA200947G3, Ctsc gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001311790, NM_009982
• Synonyms: AI047818; CatC; DPP1; DPPI
• Summary: This gene encodes a member of the peptidase C1 (papain) family of cysteine proteases. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate multiple protein products. These products include the dipeptidyl peptidase 1 light, heavy, and exclusion domain chains, which together comprise one subunit of the homotetrameric enzyme. This enzyme has amino dipeptidase activity and may play a role in the activation of granzymes during inflammation. Homozygous knockout mice for this gene exhibit impaired granzyme activation and enhanced survival in a sepsis model. [provided by RefSeq, Aug 2015]