Mouse Dao activation kit by CRISPRa

CAT#: GA201014

Dao CRISPRa kit - CRISPR gene activation of mouse D-amino acid oxidase

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: Dao
• Locus ID: 13142
• Kit Components:

  GA201014G1, Dao gRNA vector 1 in pCas-Guide-CRISPRa

  GA201014G2, Dao gRNA vector 2 in pCas-Guide-CRISPRa

  GA201014G3, Dao gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001286396, NM_001286397, NM_010018
• Synonyms: AI987963; DAAO; DAMOX; Dao-1; Dao1
• Summary: Regulates the level of the neuromodulator D-serine in the brain. Has high activity towards D-DOPA and contributes to dopamine synthesis. Could act as a detoxifying agent which removes D-amino acids accumulated during aging. Acts on a variety of D-amino acids with a preference for those having small hydrophobic side chains followed by those bearing polar, aromatic, and basic groups. Does not act on acidic amino acids. [UniProtKB/Swiss-Prot Function]