Mouse Eln activation kit by CRISPRa

CAT#: GA201227

Eln CRISPRa kit - CRISPR gene activation of mouse elastin

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: Eln
• Locus ID: 13717
• Kit Components:

  GA201227G1, Eln gRNA vector 1 in pCas-Guide-CRISPRa

  GA201227G2, Eln gRNA vector 2 in pCas-Guide-CRISPRa

  GA201227G3, Eln gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_007925
• Synonyms: AI385707; AI480567; E030024M20Rik
• Summary: This gene encodes elastin, the extracellular matrix protein that forms a major structural component of several tissues including lungs and arterial walls. Cleavage of the signal peptide from the encoded precursor generates soluble tropoelastin which undergoes lysine-derived crosslinking to form elastin polymers. Mice lacking the encoded protein exhibit defective lung development, and die of an obstructive arterial disease resulting from subendothelial cell proliferation and reorganization of smooth muscle. [provided by RefSeq, Aug 2015]