Mouse Klk1 activation kit by CRISPRa

CAT#: GA202331

Klk1 CRISPRa kit - CRISPR gene activation of mouse kallikrein 1

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: Klk1
• Locus ID: 16612
• Kit Components:

  GA202331G1, Klk1 gRNA vector 1 in pCas-Guide-CRISPRa

  GA202331G2, Klk1 gRNA vector 2 in pCas-Guide-CRISPRa

  GA202331G3, Klk1 gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001320331, NM_001320332, NM_010639
• Synonyms: 0610007D04Rik; Kal; KAL-B; Klk1b6; Klk6; mGk-6
• Summary: This gene encodes a member of the kallikrein subfamily of serine proteases that are involved in diverse physiological functions such as skin desquamation, tooth enamel formation, seminal liquefaction, synaptic neural plasticity and brain function. The encoded preproprotein undergoes proteolytic cleavage of the activation peptide to generate the functional enzyme. Mice lacking the encoded protein are unable to generate significant levels of kinins in most tissues, develop cardiovascular abnormalities and exhibit hypercalciuria of renal origin. This gene is located in a cluster of several related kallikrein genes on chromosome 7. Alternative splicing results in multiple transcript variants encoding different isoforms, some of which may undergo similar processing. [provided by RefSeq, Feb 2016]