Mouse Msh5 activation kit by CRISPRa

CAT#: GA202721

Msh5 CRISPRa kit - CRISPR gene activation of mouse mutS homolog 5

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: Msh5
• Locus ID: 17687
• Kit Components:

  GA202721G1, Msh5 gRNA vector 1 in pCas-Guide-CRISPRa

  GA202721G2, Msh5 gRNA vector 2 in pCas-Guide-CRISPRa

  GA202721G3, Msh5 gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001146215, NM_013600, NR_130640, NR_130641
• Synonyms: Mut5
• Summary: This gene encodes a member of the MutS family of proteins that play critical roles in DNA mismatch repair and meiotic homologous recombination processes. Mice lacking the encoded protein are viable but sterile, with severe defects in spermatogenesis in males and complete loss of ovarian structures in females. Mutations in a similar gene in humans have been shown to cause common variable immune deficiency (CVID) and immunoglobulin A deficiency. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jan 2015]