Mouse Mx1 activation kit by CRISPRa

CAT#: GA202773

Mx1 CRISPRa kit - CRISPR gene activation of mouse MX dynamin-like GTPase 1

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: Mx1
• Locus ID: 17857
• Kit Components:

  GA202773G1, Mx1 gRNA vector 1 in pCas-Guide-CRISPRa

  GA202773G2, Mx1 gRNA vector 2 in pCas-Guide-CRISPRa

  GA202773G3, Mx1 gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_010846, NR_003520
• Synonyms: AI893580; Mx; Mx-1
• Summary: This gene encodes a member of the Mx protein family of large GTPases, and functions in the innate immunity system. Interferon alpha/beta treatment or viral infection induces expression of this protein, which subsequently accumulates in the cytoplasm and inhibits viral replication. It has been shown to confer resistance to the influenza virus. This gene produces a functional protein in some feral mouse strains, whereas some inbred mouse strains including the strain of the reference genome, C57BL/6J, contain a deletion or a nonsense mutation that results in a non-functional gene product. [provided by RefSeq, Aug 2015]