Mouse Sigmar1 activation kit by CRISPRa

CAT#: GA203053

Sigmar1 CRISPRa kit - CRISPR gene activation of mouse sigma non-opioid intracellular receptor 1

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: Sigmar1
• Locus ID: 18391
• Kit Components:

  GA203053G1, Sigmar1 gRNA vector 1 in pCas-Guide-CRISPRa

  GA203053G2, Sigmar1 gRNA vector 2 in pCas-Guide-CRISPRa

  GA203053G3, Sigmar1 gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001286538, NM_001286539, NM_001286540, NM_001286541, NM_001286542, NM_001286551, NM_001286605, NM_011014
• Synonyms: Oprs1; Sig1R; sigma1R
• Summary: This gene encodes a transmembrane protein located in the endoplasmic reticulum. The encoded protein is a receptor that binds several endogenous ligands, including N,N-dimethyltryptamine, progesterone and pregnenolone and a variety of of non-opiate compounds. The encoded protein plays a role in regulating the activity of ion channels, acting as a chaperone and protecting cells from oxidative stress. In humans, this receptor has been associated with Alzheimer's and Parkinson's diseases, stroke and numerous disease conditions such as depression, pain and addiction. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Nov 2013]