Mouse Pax6 activation kit by CRISPRa

CAT#: GA203104

Pax6 CRISPRa kit - CRISPR gene activation of mouse paired box 6

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: Pax6
• Locus ID: 18508
• Kit Components:

  GA203104G1, Pax6 gRNA vector 1 in pCas-Guide-CRISPRa

  GA203104G2, Pax6 gRNA vector 2 in pCas-Guide-CRISPRa

  GA203104G3, Pax6 gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001244198, NM_001244200, NM_001244201, NM_001244202, NM_001310144, NM_001310145, NM_001310146, NM_013627
• Synonyms: 1500038E17Rik; AEY11; Dey; Gsfaey11; Pax-6; Sey
• Summary: This gene encodes a homeobox-containing protein that functions as a regulator of transcription. It plays a key role in the development of neural tissues, particularly the eye. Activity of this protein is also required for expression of glucagon in the pancreas. This gene is regulated by multiple enhancers located up to tens or hundreds of kilobases upstream and downstream of the transcription start sites. Mutations in this gene or deletion of these regulatory elements results in severe defects in eye development. Alternative splicing and the use of alternative promoters results in multiple transcript variants, some of which encode proteins that lack the N-terminal paired domain. [provided by RefSeq, Jul 2015]