Mouse Per1 activation kit by CRISPRa

CAT#: GA203176

Per1 CRISPRa kit - CRISPR gene activation of mouse period circadian clock 1

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: Per1
• Locus ID: 18626
• Kit Components:

  GA203176G1, Per1 gRNA vector 1 in pCas-Guide-CRISPRa

  GA203176G2, Per1 gRNA vector 2 in pCas-Guide-CRISPRa

  GA203176G3, Per1 gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001159367, NM_011065
• Synonyms: Hftm; m-rigui; mPer1; Per
• Summary: This gene is a member of the Period family of genes and is expressed in a circadian pattern in the suprachiasmatic nucleus, the primary circadian pacemaker in the mammalian brain. Genes in this family encode components of the circadian rhythms of locomotor activity, metabolism, and behavior. This gene is upregulated by Clock/Arntl heterodimers but then represses this upregulation in a feedback loop using Per/Cry heterodimers to interact with Clock/Arntl. Polymorphisms in this gene may increase the risk of getting certain cancers. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jan 2014]