Mouse Traf6 activation kit by CRISPRa

CAT#: GA204439

Traf6 CRISPRa kit - CRISPR gene activation of mouse TNF receptor-associated factor 6

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: Traf6
• Locus ID: 22034
• Kit Components:

  GA204439G1, Traf6 gRNA vector 1 in pCas-Guide-CRISPRa

  GA204439G2, Traf6 gRNA vector 2 in pCas-Guide-CRISPRa

  GA204439G3, Traf6 gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001303273, NM_009424
• Synonyms: 2310003F17Rik; AI851288; C630032O20Rik
• Summary: This gene encodes a member of the TNF receptor associated factor (TRAF) family of adaptor proteins that mediate signaling events from members of the TNF receptor and Toll/IL-1 receptor families to activate transcription factors such as NF-kappa-B and AP-1. The product of this gene is essential for perinatal and postnatal survival. Mice deficient in this protein exhibit osteopetrosis and defective in development of epidermal appendixes, normal B cell differentiation, lymph node organogenesis, interleukin-1 signaling, lipopolysaccharide signaling and neural tube closure. This protein possesses ubiquitin ligase activity. Alternate splicing of this gene results in multiple transcript variants. [provided by RefSeq, Dec 2014]