Mouse Ttr activation kit by CRISPRa

CAT#: GA204486

Ttr CRISPRa kit - CRISPR gene activation of mouse transthyretin

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: Ttr
• Locus ID: 22139
• Kit Components:

  GA204486G1, Ttr gRNA vector 1 in pCas-Guide-CRISPRa

  GA204486G2, Ttr gRNA vector 2 in pCas-Guide-CRISPRa

  GA204486G3, Ttr gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_013697
• Synonyms: AA408768; AI787086; D17860; prealbumin
• Summary: This gene encodes a carrier protein responsible for the transport of thyroid hormones and retinol. The protein consists of a tetramer of identical subunits. Due to increased stability of the tetramer form of this encoded protein in mouse, compared to the human protein, this gene product has a reduced tendency to form amyloid fibrils. In humans, this protein binds beta-amyloid preventing its aggregation and providing a neuroprotective role in Alzheimer's disease. [provided by RefSeq, Mar 2010]