Mouse Ghrl activation kit by CRISPRa

CAT#: GA206318

Ghrl CRISPRa kit - CRISPR gene activation of mouse ghrelin

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: Ghrl
• Locus ID: 58991
• Kit Components:

  GA206318G1, Ghrl gRNA vector 1 in pCas-Guide-CRISPRa

  GA206318G2, Ghrl gRNA vector 2 in pCas-Guide-CRISPRa

  GA206318G3, Ghrl gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001286404, NM_001286405, NM_001286406, NM_021488, NR_138135
• Synonyms: 2210006E23Rik; Ghr; m46; MTLRP; MTLRPAP
• Summary: This gene encodes a preproprotein that undergoes proteolytic processing to yield two bioactive peptides, ghrelin and obestatin. The hormone ghrelin plays a role in enhancing appetite and has numerous other biological functions that include stimulating the secretion of growth hormone (somatotropin) from the anterior pituitary gland. Obestatin is thought to be a hormone that functions in decreasing appetite. Mice lacking the encoded protein develop normally and exhibit no gross anatomical abnormalities. This gene encodes distinct isoforms, some or all of which may undergo similar proteolytic processing. [provided by RefSeq, Jul 2016]