Mouse Arfgap2 activation kit by CRISPRa

CAT#: GA210692

Arfgap2 CRISPRa kit - CRISPR gene activation of mouse ADP-ribosylation factor GTPase activating protein 2

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: Arfgap2
• Locus ID: 77038
• Kit Components:

  GA210692G1, Arfgap2 gRNA vector 1 in pCas-Guide-CRISPRa

  GA210692G2, Arfgap2 gRNA vector 2 in pCas-Guide-CRISPRa

  GA210692G3, Arfgap2 gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001166024, NM_023854
• Synonyms: 2310032E02Rik; Zfp289
• Summary: This gene encodes a zinc-finger-containing GTPase-activating protein for ADP ribosylation factor 1 (ARF1), a small GTPase that plays a role in coatomer-mediated vesicular trafficking. This gene product stimulates the hydrolysis of ARF1-bound GTP, which may lead to dissociation of coatomer from Golgi-derived membranes to allow fusion with target membranes. It may regulate the retrograde transport from the Golgi complex to the endoplasmic reticulum. Expression of this gene has been shown to be controlled by inhibitor of DNA binding 1 (Id1). Alternatively spliced transcript variants encoding different isoforms have been found for this gene. A pseudogene of this gene was identified on chromosome 6. [provided by RefSeq, Oct 2009]