Mouse Rdh12 activation kit by CRISPRa

CAT#: GA210852

Rdh12 CRISPRa kit - CRISPR gene activation of mouse retinol dehydrogenase 12

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: Rdh12
• Locus ID: 77974
• Kit Components:

  GA210852G1, Rdh12 gRNA vector 1 in pCas-Guide-CRISPRa

  GA210852G2, Rdh12 gRNA vector 2 in pCas-Guide-CRISPRa

  GA210852G3, Rdh12 gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001313971, NM_030017
• Summary: The protein encoded by this gene is an NADPH-dependent retinal reductase whose highest activity is toward 9-cis and all-trans-retinol. The encoded enzyme also plays a role in the metabolism of short-chain aldehydes but does not exhibit steroid dehydrogenase activity. Defects in the human gene are associated with Leber congenital amaurosis type 13, and Retinitis Pigmentosa 53. [provided by RefSeq, Sep 2015]