Mouse Hamp activation kit by CRISPRa

CAT#: GA211287

Hamp CRISPRa kit - CRISPR gene activation of mouse hepcidin antimicrobial peptide

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: Hamp
• Locus ID: 84506
• Kit Components:

  GA211287G1, Hamp gRNA vector 1 in pCas-Guide-CRISPRa

  GA211287G2, Hamp gRNA vector 2 in pCas-Guide-CRISPRa

  GA211287G3, Hamp gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_032541
• Synonyms: Hamp1; Hepc; Hepc1
• Summary: This gene encodes hepcidin, an antimicrobial peptide and master hormonal regulator of systemic iron metabolism. The encoded preproprotein is synthesized in the hepatocytes where it undergoes proteolytic processing to generate disulfide-linked mature peptides that are secreted into the bloodstream. Mice lacking the encoded protein develop multivisceral iron overlaod, with sparing of the spleen macrophages. Certain mutations in the human ortholog of this gene cause hemochromatosis type 2B, also known as juvenile hemochromatosis. This gene is located adjacent to a related hepcidin gene on chromosome 7. [provided by RefSeq, Aug 2016]