PC1/3 (PCSK1) Human Gene Knockout Kit (CRISPR)
CAT#: KN221711
PCSK1 - human gene knockout kit via CRISPR, HDR mediated
HDR-mediated knockout kit validation
USD 1,290.00
2 Weeks*
Specifications
Product Data | |
Format | 2 gRNA vectors, 1 GFP-puro donor, 1 scramble control |
Donor DNA | GFP-puro |
Symbol | PCSK1 |
Locus ID | 5122 |
Disclaimer | The kit is designed based on the best knowledge of CRISPR technology. The system has been functionally validated for knocking-in the cassette downstream the native promoter. The efficiency of the knock-out varies due to the nature of the biology and the complexity of the experimental process. |
Reference Data | |
RefSeq | NM_000439, NM_001177875, NM_001177876 |
Synonyms | BMIQ12; NEC1; PC1; PC3; SPC3 |
Summary | This gene encodes a member of the subtilisin-like proprotein convertase family, which includes proteases that process protein and peptide precursors trafficking through regulated or constitutive branches of the secretory pathway. The encoded protein undergoes an initial autocatalytic processing event in the ER to generate a heterodimer which exits the ER and sorts to subcellular compartments where a second autocatalytic even takes place and the catalytic activity is acquired. The protease is packaged into and activated in dense core secretory granules and expressed in the neuroendocrine system and brain. This gene encodes one of the seven basic amino acid-specific members which cleave their substrates at single or paired basic residues. It functions in the proteolytic activation of polypeptide hormones and neuropeptides precursors. Mutations in this gene have been associated with susceptibility to obesity and proprotein convertase 1/3 deficiency. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene [provided by RefSeq, Jan 2014] |
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Other Versions
SKU | Description | Size | Price |
---|---|---|---|
KN221711BN | PCSK1 - human gene knockout kit via CRISPR, HDR mediated |
USD 1,290.00 |
|
KN221711LP | PCSK1 - human gene knockout kit via CRISPR, HDR mediated |
USD 1,290.00 |
|
KN221711RB | PCSK1 - human gene knockout kit via CRISPR, HDR mediated |
USD 1,290.00 |
|
KN421711 | PCSK1 - KN2.0, Human gene knockout kit via CRISPR, non-homology mediated. |
USD 1,290.00 |
|
GA103423 | PCSK1 CRISPRa kit - CRISPR gene activation of human proprotein convertase subtilisin/kexin type 1 |
USD 1,290.00 |
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