HNRPH1 (HNRNPH1) Human Gene Knockout Kit (CRISPR)

CAT#: KN401834

HNRNPH1 - KN2.0, Human gene knockout kit via CRISPR, non-homology mediated.

Product Images

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Specifications

Product Data

• Format: 2 gRNA vectors, 1 linear donor
• Donor DNA: EF1a-GFP-P2A-Puro
• Symbol: HNRPH1
• Locus ID: 3187
• Disclaimer: The kit is designed based on the best knowledge of CRISPR technology. The system has been functionally validated for knocking-in the cassette downstream the native promoter. The efficiency of the knock-out varies due to the nature of the biology and the complexity of the experimental process.

Reference Data

• RefSeq: NM_001257293, NM_005520, NM_001364233, NM_001363572, NM_001364227, NM_001364228, NM_001364234, NM_001364236, NM_001364237, NM_001364239, NM_001364242, NM_001364244, NM_001364245, NM_001364247, NM_001364251, NM_001364252, NM_001364253, NM_001364255, NM_001364225, NM_001364226, NM_001364229, NM_001364230, NM_001364231, NM_001364232, NM_001364235, NM_001364238, NM_001364240, NM_001364241, NM_001364243, NM_001364246, NM_001364248, NM_001364250, NM_001364254
• Synonyms: hnRNPH; HNRPH; HNRPH1
• Summary: 'This gene encodes a member of a subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The hnRNPs are RNA binding proteins that complex with heterogeneous nuclear RNA. These proteins are associated with pre-mRNAs in the nucleus and appear to influence pre-mRNA processing and other aspects of mRNA metabolism and transport. While all of the hnRNPs are present in the nucleus, some may shuttle between the nucleus and the cytoplasm. The hnRNP proteins have distinct nucleic acid binding properties. The protein encoded by this gene has three repeats of quasi-RRM domains that bind to RNA and is very similar to the family member HNRPF. This gene may be associated with hereditary lymphedema type I. Alternatively spliced transcript variants have been described [provided by RefSeq, Mar 2012]'