RGS6 Human Gene Knockout Kit (CRISPR)

CAT#: KN411189

RGS6 - KN2.0, Human gene knockout kit via CRISPR, non-homology mediated.

Product Images

Specifications

Product Data

• Format: 2 gRNA vectors, 1 linear donor
• Donor DNA: EF1a-GFP-P2A-Puro
• Symbol: RGS6
• Locus ID: 9628
• Disclaimer: The kit is designed based on the best knowledge of CRISPR technology. The system has been functionally validated for knocking-in the cassette downstream the native promoter. The efficiency of the knock-out varies due to the nature of the biology and the complexity of the experimental process.

Reference Data

• RefSeq: NM_001204416, NM_001204417, NM_001204418, NM_001204419, NM_001204420, NM_001204421, NM_001204422, NM_001204423, NM_001204424, NM_004296, NR_135235, NM_001370270, NM_001370271, NM_001370272, NM_001370273, NM_001370274, NM_001370276, NM_001370278, NM_001370281, NM_001370284, NM_001370290, NM_001370275, NM_001370277, NM_001370279, NM_001370280, NM_001370282, NM_001370283, NM_001370286, NM_001370287, NM_001370288, NM_001370289, NM_001370291, NM_001370292, NM_001370293, NM_001370294
• Synonyms: GAP
• Summary: This gene encodes a member of the RGS (regulator of G protein signaling) family of proteins, which are defined by the presence of a RGS domain that confers the GTPase-activating activity of these proteins toward certain G alpha subunits. This protein also belongs to a subfamily of RGS proteins characterized by the presence of DEP and GGL domains, the latter a G beta 5-interacting domain. The RGS proteins negatively regulate G protein signaling, and may modulate neuronal, cardiovascular, lymphocytic activities, and cancer risk. Many alternatively spliced transcript variants encoding different isoforms with long or short N-terminal domains, complete or incomplete GGL domains, and distinct C-terminal domains, have been described for this gene, however, the full-length nature of some of these variants is not known. [provided by RefSeq, Mar 2011]