HPS1 Human Gene Knockout Kit (CRISPR)

CAT#: KN413679

HPS1 - KN2.0, Human gene knockout kit via CRISPR, non-homology mediated.

Product Images

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Specifications

Product Data

• Format: 2 gRNA vectors, 1 linear donor
• Donor DNA: EF1a-GFP-P2A-Puro
• Symbol: HPS1
• Locus ID: 3257
• Disclaimer: The kit is designed based on the best knowledge of CRISPR technology. The system has been functionally validated for knocking-in the cassette downstream the native promoter. The efficiency of the knock-out varies due to the nature of the biology and the complexity of the experimental process.

Reference Data

• RefSeq: NM_000195, NM_182637, NM_182638, NM_182639, NM_001311345, NM_001322476, NM_001322477, NM_001322478, NM_001322479, NM_001322480, NM_001322481, NM_001322482, NM_001322483, NM_001322484, NM_001322485, NM_001322487, NM_001322489, NM_001322490, NM_001322491, NM_001322492
• Synonyms: HPS
• Summary: 'This gene encodes a protein that may play a role in organelle biogenesis associated with melanosomes, platelet dense granules, and lysosomes. The encoded protein is a component of three different protein complexes termed biogenesis of lysosome-related organelles complex (BLOC)-3, BLOC4, and BLOC5. Mutations in this gene are associated with Hermansky-Pudlak syndrome type 1. Alternative splicing results in multiple transcript variants. A pseudogene related to this gene is located on chromosome 22. [provided by RefSeq, Aug 2015]'