UCKL1 Human Gene Knockout Kit (CRISPR)

CAT#: KN417118

UCKL1 - KN2.0, Human gene knockout kit via CRISPR, non-homology mediated.

Product Images

Specifications

Product Data

• Format: 2 gRNA vectors, 1 linear donor
• Donor DNA: EF1a-GFP-P2A-Puro
• Symbol: UCKL1
• Locus ID: 54963
• Disclaimer: The kit is designed based on the best knowledge of CRISPR technology. The system has been functionally validated for knocking-in the cassette downstream the native promoter. The efficiency of the knock-out varies due to the nature of the biology and the complexity of the experimental process.

Reference Data

• RefSeq: NM_001193379, NM_017859, NR_126526, NM_001353475, NM_001353476, NM_001353477, NM_001353478, NM_001353479, NM_001353480, NM_001353481, NM_001353482, NR_148434, NR_148435, NR_148436, NR_148437, NR_148438, NR_148439, NR_148440, NR_148441, NR_148442
• Synonyms: UCK1L; URKL1
• Summary: The protein encoded by this gene is a uridine kinase. Uridine kinases catalyze the phosphorylation of uridine to uridine monophosphate. This protein has been shown to bind to Epstein-Barr nuclear antigen 3 as well as natural killer lytic-associated molecule. Ubiquitination of this protein is enhanced by the presence of natural killer lytic-associated molecule. In addition, protein levels decrease in the presence of natural killer lytic-associated molecule, suggesting that association with natural killer lytic-associated molecule results in ubiquitination and subsequent degradation of this protein. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2014]