Natriuretic peptides B (1-32) Human Protein
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Specifications
Product Data | |
Species | Human |
Expression cDNA Clone or AA Sequence |
NH2-SPKMVQGSGCFGRKMDRISSSSGLGCKVLRRH-OH
|
Predicted MW | 3466.06 Da |
Purity | >95% by HPLC |
Buffer | State: Purified peptide |
Preparation | Purified peptide |
Protein Description | Human Brain natriuretic peptide (1-32). Formula: C143H224N50O42S4 |
Storage | Upon receipt, store undiluted (in aliquots) at -20°C. Avoid repeated freezing and thawing. |
Stability | Shelf life: One year from despatch. |
Reference Data | |
RefSeq | NP_002512 |
Locus ID | 4879 |
Cytogenetics | 1p36.22 |
Synonyms | BNP |
Summary | 'This gene is a member of the natriuretic peptide family and encodes a secreted protein which functions as a cardiac hormone. The protein undergoes two cleavage events, one within the cell and a second after secretion into the blood. The protein's biological actions include natriuresis, diuresis, vasorelaxation, inhibition of renin and aldosterone secretion, and a key role in cardiovascular homeostasis. A high concentration of this protein in the bloodstream is indicative of heart failure. The presence of myocardial injury is a significant predictor of mortality in hospitalized coronavirus disease 2019 (COVID-19) patients, and there is evidence of increased levels of natriuretic peptide B in hospitalized non-survivor COVID-19 patients. The protein also acts as an antimicrobial peptide with antibacterial and antifungal activity. Mutations in this gene have been associated with postmenopausal osteoporosis. [provided by RefSeq, Aug 2020]' |
Protein Families | Druggable Genome, Secreted Protein, Stem cell - Pluripotency |
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