PGPEP1 (NM_017712) Human Recombinant Protein

CAT#: TP314837

Recombinant protein of human pyroglutamyl-peptidase I (PGPEP1)

Product Images

Coomassie blue staining of purified PGPEP1 protein (Cat# TP314837). The protein was produced from HEK293T cells transfected with PGPEP1 cDNA clone (Cat# RC214837) using MegaTran 2.0 (Cat# TT210002).

Specifications

Product Data

• Species: Human
• Expression Host: HEK293T
• Expression cDNA Clone or AA Sequence:
  Protein Sequence

  Recombinant protein was produced with TrueORF clone, RC214837. Click on the TrueORF clone link to view cDNA and protein sequences.
• Tag: C-Myc/DDK
• Predicted MW: 23 kDa
• Concentration: >50 ug/mL as determined by microplate BCA method
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining
• Buffer: 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol
• Preparation: Recombinant protein was captured through anti-DDK affinity column followed by conventional chromatography steps.
• Storage: Store at -80°C.
• Stability: Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.

Reference Data

• RefSeq: NP_060182
• Locus ID: 54858
• UniProt ID: Q9NXJ5
• Cytogenetics: 19p13.11
• Refseq Size: 2239
• Refseq ORF: 627
• Synonyms: PAP-I; Pcp; PGI; PGP; PGP-I; PGPI
• Summary: The gene encodes a cysteine protease and member of the peptidase C15 family of proteins. The encoded protein cleaves amino terminal pyroglutamate residues from protein substrates including thyrotropin-releasing hormone and other neuropeptides. Expression of this gene may be downregulated in colorectal cancer, while activity of the encoded protein may be negatively correlated with cancer progression in colorectal cancer patients. Activity of the encoded protease may also be altered in other disease states including in liver cirrhosis, which is associated with reduced protease activity, and in necrozoospermia, which is associated with elevated protease activity. [provided by RefSeq, Jul 2016]
• Protein Families: Druggable Genome, Protease