LAMC2 (NM_005562) Human Recombinant Protein
CAT#: TP322076
Recombinant protein of human laminin, gamma 2 (LAMC2), transcript variant 1
View other "LAMC2" proteins (9)
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Specifications
Product Data | |
Species | Human |
Expression Host | HEK293T |
Expression cDNA Clone or AA Sequence |
Recombinant protein was produced with TrueORF clone, RC222076. Click on the TrueORF clone link to view cDNA and protein sequences.
|
Tag | C-Myc/DDK |
Predicted MW | 128.7 kDa |
Concentration | >50 ug/mL as determined by microplate BCA method |
Purity | > 80% as determined by SDS-PAGE and Coomassie blue staining |
Buffer | 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol |
Preparation | Recombinant protein was captured through anti-DDK affinity column followed by conventional chromatography steps. |
Storage | Store at -80°C. |
Stability | Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles. |
Reference Data | |
RefSeq | NP_005553 |
Locus ID | 3918 |
UniProt ID | Q13753 |
Cytogenetics | 1q25.3 |
Refseq Size | 5175 |
Refseq ORF | 3579 |
Synonyms | B2T; BM600; CSF; EBR2; EBR2A; LAMB2T; LAMNB2 |
Summary | 'Laminins, a family of extracellular matrix glycoproteins, are the major noncollagenous constituent of basement membranes. They have been implicated in a wide variety of biological processes including cell adhesion, differentiation, migration, signaling, neurite outgrowth and metastasis. Laminins, composed of 3 non identical chains: laminin alpha, beta and gamma (formerly A, B1, and B2, respectively), have a cruciform structure consisting of 3 short arms, each formed by a different chain, and a long arm composed of all 3 chains. Each laminin chain is a multidomain protein encoded by a distinct gene. Several isoforms of each chain have been described. Different alpha, beta and gamma chain isomers combine to give rise to different heterotrimeric laminin isoforms which are designated by Arabic numerals in the order of their discovery, i.e. alpha1beta1gamma1 heterotrimer is laminin 1. The biological functions of the different chains and trimer molecules are largely unknown, but some of the chains have been shown to differ with respect to their tissue distribution, presumably reflecting diverse functions in vivo. This gene encodes the gamma chain isoform laminin, gamma 2. The gamma 2 chain, formerly thought to be a truncated version of beta chain (B2t), is highly homologous to the gamma 1 chain; however, it lacks domain VI, and domains V, IV and III are shorter. It is expressed in several fetal tissues but differently from gamma 1, and is specifically localized to epithelial cells in skin, lung and kidney. The gamma 2 chain together with alpha 3 and beta 3 chains constitute laminin 5 (earlier known as kalinin), which is an integral part of the anchoring filaments that connect epithelial cells to the underlying basement membrane. The epithelium-specific expression of the gamma 2 chain implied its role as an epithelium attachment molecule, and mutations in this gene have been associated with junctional epidermolysis bullosa, a skin disease characterized by blisters due to disruption of the epidermal-dermal junction. Two tr' |
Protein Families | Druggable Genome, Secreted Protein |
Protein Pathways | ECM-receptor interaction, Focal adhesion, Pathways in cancer, Small cell lung cancer |
Documents
FAQs |
SDS |
Resources
Recombinant Protein Resources |
Other Versions
SKU | Description | Size | Price |
---|---|---|---|
LC412907 | LAMC2 HEK293T cell transient overexpression lysate (as WB positive control) |
USD 187.00 |
|
LC417224 | LAMC2 HEK293T cell transient overexpression lysate (as WB positive control) |
USD 187.00 |
|
LC429255 | LAMC2 HEK293T cell transient overexpression lysate (as WB positive control) |
USD 187.00 |
|
LY412907 | Transient overexpression lysate of laminin, gamma 2 (LAMC2), transcript variant 2 |
USD 605.00 |
|
LY417224 | Transient overexpression lysate of laminin, gamma 2 (LAMC2), transcript variant 1 |
USD 605.00 |
|
LY429255 | Transient overexpression lysate of laminin, gamma 2 (LAMC2), transcript variant 1 |
USD 605.00 |
|
PH318516 | LAMC2 MS Standard C13 and N15-labeled recombinant protein (NP_061486) |
USD 2,055.00 |
|
PH322076 | LAMC2 MS Standard C13 and N15-labeled recombinant protein (NP_005553) |
USD 2,055.00 |
|
TP318516 | Recombinant protein of human laminin, gamma 2 (LAMC2), transcript variant 2 |
USD 788.00 |
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